(19)

(11)

EP 4 558 481 A1

(12)

(43) Date of publication: 28.05.2025 Bulletin 2025/22 (21) Application number: 23757730.9 (22) Date of filing: 20.07.2023

(51) International Patent Classification (IPC):  C07D 205/12(2006.01) C07D 401/14(2006.01) C07D 403/12(2006.01) C07D 405/14(2006.01) A61K 31/397(2006.01) A61P 25/14(2006.01) C07D 401/12(2006.01) C07D 403/04(2006.01) C07D 403/14(2006.01) C07D 413/14(2006.01) A61K 31/00(2006.01) A61P 25/28(2006.01) (52) Cooperative Patent Classification (CPC): A61P 25/14; A61P 25/28; C07D 205/12; C07D 401/12; C07D 401/14; C07D 403/04; C07D 403/12; C07D 403/14; C07D 405/14; C07D 413/14 (86) International application number: PCT/US2023/028271 (87) International publication number: WO 2024/020156 (25.01.2024 Gazette 2024/04)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 22.07.2022 US 202263391578 P (71) Applicant: Biogen MA Inc. Cambridge, MA 02142 (US)	(72) Inventors: GONZALEZ LOPEZ DE TURISO, Felix Cambridge, MA 02142 (US) HIMMELBAUER, Martin Cambridge, MA 02142 (US) JONES, John H. Cambridge, MA 02142 (US) PATTAROPONG, Vatee Cambridge, MA 02142 (US) PRINCE, Robin Cambridge, MA 02142 (US) XIN, Zhili Cambridge, MA 02142 (US) (74) Representative: HGF  HGF Limited 1 City Walk Leeds LS11 9DX Leeds LS11 9DX (GB)