(19)

(11)

EP 4 558 514 A2

(12)

(88) Date of publication A3: 07.03.2024 (43) Date of publication: 28.05.2025 Bulletin 2025/22 (21) Application number: 23843942.6 (22) Date of filing: 21.07.2023

(51) International Patent Classification (IPC):  C07K 14/47(2006.01) C12N 15/86(2006.01) A61K 48/00(2006.01) C12Q 1/6883(2018.01) (52) Cooperative Patent Classification (CPC): C12N 15/86; C12N 2830/008; C12N 2750/14143; C12N 2830/48; C12N 2830/50; C12N 2830/38; A61K 38/00; A61K 48/0058; C12N 2800/22; A61K 48/005; A61K 45/06; A61P 19/00 (86) International application number: PCT/US2023/070765 (87) International publication number: WO 2024/020574 (25.01.2024 Gazette 2024/04)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 21.07.2022 US 202263391252 P (71) Applicant: New York University New York, NY 10012 (US)

(72) Inventors: ABBADI, Dounia New York, NY 10016 (US) SCHNEIDER, Robert, J. New York, NY 10003 (US) KARUMUTHIL-MELETHIL, Subha Rockville, MD 20850 (US) QIAO, Chunping Rockville, MD 20850 (US) ELLIOTT, Kirk Rockville, MD 20850 (US) LIU, Ye Rockville, MD 20850 (US) DANOS, Olivier Rockville, MD 20850 (US) FOLTZ, Steven Rockville, MD 20850 (US) (74) Representative: Keltie LLP  No. 1 London Bridge London SE1 9BA London SE1 9BA (GB)