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EP 4 558 624 A2

(12)

(88) Date of publication A3: 29.02.2024 (43) Date of publication: 28.05.2025 Bulletin 2025/22 (21) Application number: 23754608.0 (22) Date of filing: 17.07.2023

(51) International Patent Classification (IPC):  C12N 9/22(2006.01) C12N 15/113(2010.01) C12N 15/10(2006.01) C12N 15/90(2006.01) (52) Cooperative Patent Classification (CPC): C12N 9/22; C12N 15/88; C12N 15/907; C12Y 301/00 (86) International application number: PCT/US2023/070339 (87) International publication number: WO 2024/020346 (25.01.2024 Gazette 2024/04)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 18.07.2022 US 202263368722 P 18.07.2022 US 202263368724 P 18.07.2022 US 202263368726 P 18.07.2022 US 202263368728 P 18.07.2022 US 202263368730 P 18.07.2022 US 202263368731 P 18.07.2022 US 202263368734 P 18.07.2022 US 202263368735 P 18.07.2022 US 202263368736 P 18.07.2022 US 202263368737 P 18.07.2022 US 202263368738 P 18.07.2022 US 202263368741 P 18.07.2022 US 202263368742 P 18.07.2022 US 202263368744 P 07.04.2023 US 202318297346 10.04.2023 US 202363495198 P (71) Applicant: Renagade Therapeutics Management Inc. Cambridge, Massachusetts 02139 (US)

(72) Inventors: GASIUNAS, Giedrius 10257 Vilnius (LT) LADHA, Alim Cambridge, MA 02139 (US) PRESNYAK, Vladimir Cambridge, MA 02139 (US) JAYARAMAN, Muthusamy Cambridge, MA 02139 (US) NARAYANAN, Elisabeth Watertown, MA 02472 (US) (74) Representative: Atkins, James Gordon John et al Kilburn & Strode LLP Lacon London 84 Theobalds Road London WC1X 8NL London WC1X 8NL (GB)