(19)

(11)

EP 4 558 625 A1

(12)

(43) Date of publication: 28.05.2025 Bulletin 2025/22 (21) Application number: 23754969.6 (22) Date of filing: 21.07.2023

(51) International Patent Classification (IPC):  C12N 9/22(2006.01) C12N 15/70(2006.01) C12N 15/10(2006.01) C12N 15/85(2006.01) (52) Cooperative Patent Classification (CPC): C12N 9/22; C07K 2319/09; C12N 15/102; C12N 15/70; C12N 15/85; C12N 2310/20; C12N 15/907; C12N 15/90 (86) International application number: PCT/US2023/070730 (87) International publication number: WO 2024/020557 (25.01.2024 Gazette 2024/04)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 22.07.2022 US 202263391684 P (71) Applicant: Arbor Biotechnologies, Inc. Cambridge, MA 02140 (US)

(72) Inventors: ALFONSE, Lauren E. Cambridge, Massachusetts 02140 (US) CHONG, Shaorong Cambridge, Massachusetts 02140 (US) GARRITY, Anthony James Cambridge, Massachusetts 02140 (US) HILBERT, Brendan Jay Cambridge, Massachusetts 02140 (US) LU, Wei-Cheng Cambridge, Massachusetts 02140 (US) MABEN, Zachary John Cambridge, Massachusetts 02140 (US) WESSELLS, Quinton Norman Cambridge, Massachusetts 02140 (US) (74) Representative: Maiwald GmbH  Elisenhof Elisenstraße 3 80335 München 80335 München (DE)