(19)

(11)

EP 4 561 561 A2

(12)

(88) Date of publication A3: 07.03.2024 (43) Date of publication: 04.06.2025 Bulletin 2025/23 (21) Application number: 23847383.9 (22) Date of filing: 28.07.2023

(51) International Patent Classification (IPC):  A61K 31/395(2006.01) A61K 31/496(2006.01) A61K 31/47(2006.01) A61K 31/33(2006.01) (52) Cooperative Patent Classification (CPC): C07D 498/04; C07D 471/04; C07D 241/44; C07D 405/10; C07D 265/36; C07D 215/227; C07D 239/80; C07D 263/58; C07D 413/06; C07D 405/06; C07D 401/06; C07D 405/12; C07D 403/12; C07D 401/12; C07D 405/04 (86) International application number: PCT/US2023/028950 (87) International publication number: WO 2024/026076 (01.02.2024 Gazette 2024/05)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 29.07.2022 US 202263393411 P (71) Applicant: Septerna, Inc. South San Francisco, CA 94080 (US)	(72) Inventors: MCKERRALL, Steven, J. San Francisco, CA 94114 (US) LONG, Daniel D. San Francisco, CA 94132 (US) DU, Xiaohui Belmont, CA 94002 (US) AYDIN, Deniz Redwood City, CA 94063 (US) VOLGRAF, Matthew Oakland, CA 94602 (US) (74) Representative: HGF  HGF Limited 1 City Walk Leeds LS11 9DX Leeds LS11 9DX (GB)