(19)
(11) EP 4 561 562 A2

(12)

(88) Date of publication A3:
14.03.2024

(43) Date of publication:
04.06.2025 Bulletin 2025/23

(21) Application number: 23847417.5

(22) Date of filing: 29.07.2023
(51) International Patent Classification (IPC): 
A61K 31/395(2006.01)
C07D 403/02(2006.01)
 A61K 31/496(2006.01)
A61K 31/33(2006.01)
(52) Cooperative Patent Classification (CPC):
C07D 487/04; C07D 333/58; C07D 513/04; C07D 209/56; C07D 471/04; C07D 471/14; C07D 498/04; A61K 45/06; A61K 31/4035; A61K 31/404; A61K 31/437
 
C-Sets:
  1. A61K 31/4035, A61K 2300/00;
  2. A61K 31/404, A61K 2300/00;
  3. A61K 31/437, A61K 2300/00;
(86) International application number:
PCT/US2023/029048
(87) International publication number:
WO 2024/026128 (01.02.2024 Gazette 2024/05)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA
Designated Validation States:
KH MA MD TN

(30) Priority: 29.07.2022 US 202263393564 P
06.06.2023 US 202363471488 P

(71) Applicant: Ensem Therapeutics, Inc.
Waltham, MA 02451 (US)

(72) Inventors:
  • LI, Mingzong
    Waltham, MA 02451 (US)
  • LIU, Tao
    Waltham, MA 02451 (US)
  • FENG, Jun
    Waltham, MA 02451 (US)
  • DENG, Hongbo
    Waltham, MA 02451 (US)
  • HAO, Minghong
    Waltham, MA 02451 (US)

(74) Representative: CH Kilger Anwaltspartnerschaft mbB 
Fasanenstraße 29
10719 Berlin
10719 Berlin (DE)

   


(54) TRICYCLIC ARYL DERIVATIVES, AND COMPOSITIONS AND METHODS THEREOF