(19)

(11)

EP 4 561 567 A2

(12)

(88) Date of publication A3: 07.03.2024 (43) Date of publication: 04.06.2025 Bulletin 2025/23 (21) Application number: 23847619.6 (22) Date of filing: 28.07.2023

(51) International Patent Classification (IPC):  A61K 31/395(2006.01) A61K 31/4196(2006.01) A61K 31/4162(2006.01) A61K 31/33(2006.01) (52) Cooperative Patent Classification (CPC): C07D 471/04; A61P 25/28 (86) International application number: PCT/US2023/071289 (87) International publication number: WO 2024/026500 (01.02.2024 Gazette 2024/05)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 28.07.2022 US 202263393187 P 05.08.2022 US 202263370546 P (71) Applicants: University of Maryland, Baltimore Baltimore, MD 21201 (US) Montclair State University Montclair, New Jersey 07043 (US)

(72) Inventors: KELLY, Michele, Patrice Fulton, MD 21075 (US) ROTELLA, David Hiawatha, NJ 07034 (US) MAHMOOD, Shams ul Cedar Grove, NJ 07009 (US) (74) Representative: Maiwald GmbH  Elisenhof Elisenstraße 3 80335 München 80335 München (DE)