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EP 4 561 618 A2

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(88) Date of publication A3: 28.03.2024 (43) Date of publication: 04.06.2025 Bulletin 2025/23 (21) Application number: 23847294.8 (22) Date of filing: 26.07.2023

(51) International Patent Classification (IPC):  A61K 39/112(2006.01) A61P 1/02(2006.01) A61K 47/36(2006.01) C12P 19/04(2006.01) A61K 31/715(2006.01) A61P 31/04(2006.01) C07K 14/005(2006.01) C12R 1/42(2006.01) (52) Cooperative Patent Classification (CPC): Y02A 50/30; C07K 14/255; A61K 39/0275; A61P 31/04; A61K 2039/575; A61K 2039/55566; A61K 2039/6075 (86) International application number: PCT/US2023/028672 (87) International publication number: WO 2024/025936 (01.02.2024 Gazette 2024/05)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 26.07.2022 US 202263392274 P (71) Applicants: Board of Trustees of Michigan State University East Lansing, MI 48824 (US) University of Maryland, Baltimore Baltimore, MD 21201 (US)

(72) Inventors: HUANG, Xuefei Okemos, MI 48864 (US) PAN, Xingling Lansing, MI 48823 (US) HUO, Chang-Xin Lansing, MI 48823 (US) BALIBAN, Scott Michael Washington, DC 20003 (US) TENNANT, Sharon Mei Ellicott City, MD 21043 (US) (74) Representative: Hoefer & Partner Patentanwälte mbB  Pilgersheimer Straße 20 81543 München 81543 München (DE)