(19)

(11)

EP 4 561 645 A2

(12)

(88) Date of publication A3: 07.03.2024 (43) Date of publication: 04.06.2025 Bulletin 2025/23 (21) Application number: 23847351.6 (22) Date of filing: 27.07.2023

(51) International Patent Classification (IPC):  A61L 26/00(2006.01) A61L 27/18(2006.01) A61L 27/50(2006.01) A61L 27/14(2006.01) A61L 27/38(2006.01) C12N 5/07(2010.01) (52) Cooperative Patent Classification (CPC): B33Y 10/00; B33Y 70/00; B33Y 80/00; B29C 64/106; A61L 27/52; A61L 27/507; A61L 27/26; A61L 27/3891; A61L 27/3808; A61L 27/3826   C-Sets: A61L 27/26, C08L 5/04; A61L 27/26, C08L 89/06; A61L 27/26, C08L 75/04; (86) International application number: PCT/US2023/028853 (87) International publication number: WO 2024/026023 (01.02.2024 Gazette 2024/05)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 27.07.2022 US 202263392792 P 12.03.2023 US 202363451633 P (71) Applicant: The Brigham & Women's Hospital, Inc. Boston, Massachusetts 02115 (US)	(72) Inventors: ZHANG, Yu Shrike Boston, Massachusetts 02115 (US) KUANG, Xiao Boston, Massachusetts 02115 (US) (74) Representative: Marks & Clerk LLP  15 Fetter Lane London EC4A 1BW London EC4A 1BW (GB)