(19)
(11) EP 4 561 697 A1

(12)

(43) Date of publication:
04.06.2025 Bulletin 2025/23

(21) Application number: 23757764.8

(22) Date of filing: 28.07.2023
(51) International Patent Classification (IPC): 
A61P 9/00(2006.01)
A61K 31/495(2006.01)
 C07D 471/04(2006.01)
(52) Cooperative Patent Classification (CPC):
A61P 9/00; C07D 471/04
(86) International application number:
PCT/US2023/028919
(87) International publication number:
WO 2024/026058 (01.02.2024 Gazette 2024/05)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA
Designated Validation States:
KH MA MD TN

(30) Priority: 29.07.2022 WO PCT/CN2022/109030

(71) Applicant: MyoKardia, Inc.
Brisbane CA 94005 (US)

(72) Inventors:
  • YU, Ying
    Brisbane, California 94005 (US)
  • ZHANG, David John
    Brisbane, California 94005 (US)
  • WANG, Juan
    Brisbane, California 94005 (US)
  • HUANG, Neal
    Brisbane, California 94005 (US)
  • LOUGHREY, Jonathan
    Brisbane, California 94005 (US)
  • SHARP, Lorraine
    Brisbane, California 94005 (US)
  • DALENS, Catherine
    Brisbane, California 94005 (US)
  • TAILLEZ, Franck
    Brisbane, California 94005 (US)
  • MENEGOTTO, Jerome
    Brisbane, California 94005 (US)
  • TUMMA, Harikirshna
    Brisbane, California 94005 (US)
  • WAN, Lin
    Brisbane, California 94005 (US)
  • WANG, Wei
    Brisbane, California 94005 (US)
  • YANG, Rongfei
    Brisbane, California 94005 (US)
  • LI, Zheng Jane
    Brisbane, California 94005 (US)
  • WANG, Ruiping
    Brisbane, California 94005 (US)
  • LU, Yue
    Brisbane, California 94005 (US)

(74) Representative: Carpmaels & Ransford LLP 
One Southampton Row
London WC1B 5HA
London WC1B 5HA (GB)

   


(54) CRYSTALLINE FORMS OF (6S,7S)-6-FLUORO-7-(2-FLUORO-5-METHYLPHENYL)- 3-(TETRAHYDRO-2H-PYRAN-4-YL)-5,6,7,8-TETRAHYDROPYRIDO[2,3- D]PYRIMIDINE-2,4(1H,3H)-DIONE