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(11)

EP 4 562 136 A1

(12)

(43) Date of publication: 04.06.2025 Bulletin 2025/23 (21) Application number: 23847591.7 (22) Date of filing: 28.07.2023

(51) International Patent Classification (IPC):  C12N 9/16(2006.01) C12N 15/52(2006.01) C12N 5/16(2006.01) C07K 14/47(2006.01) C12N 15/85(2006.01) (52) Cooperative Patent Classification (CPC): C12N 9/16; C12N 15/52; C12N 15/85; C12N 2740/16043; A01K 2227/105; A01K 2217/075; C12Y 301/04017; C12Y 301/04035; C12Y 301/04053 (86) International application number: PCT/US2023/071206 (87) International publication number: WO 2024/026454 (01.02.2024 Gazette 2024/05)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 28.07.2022 US 202263393167 P (71) Applicant: University of Maryland, Baltimore Baltimore, MD 21201 (US)	(72) Inventor: KELLY, Michele, Patrice Fulton, MD 21075 (US) (74) Representative: Maiwald GmbH  Elisenhof Elisenstraße 3 80335 München 80335 München (DE)