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(11)

EP 4 562 157 A1

(12)

(43) Date of publication: 04.06.2025 Bulletin 2025/23 (21) Application number: 23847573.5 (22) Date of filing: 27.07.2023

(51) International Patent Classification (IPC):  C12N 15/113(2010.01) C12N 15/11(2006.01) C12Q 1/6876(2018.01) A61K 31/713(2006.01) C12Q 1/68(2018.01) (52) Cooperative Patent Classification (CPC): C12N 15/113; A61K 31/713; C12N 2310/113; A61P 37/00 (86) International application number: PCT/US2023/071135 (87) International publication number: WO 2024/026418 (01.02.2024 Gazette 2024/05)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 28.07.2022 US 202263393228 P (71) Applicant: New York University New York, NY 10012 (US)	(72) Inventors: MOORE, Kathryn J. Westfield, NJ 07090 (US) VAN SOLINGEN, Coen New York, NY 10026 (US) CYR, Yannick New York, NY 10016 (US) (74) Representative: FRKelly  Waterways House Grand Canal Quay Dublin D02 PD39 Dublin D02 PD39 (IE)