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(11)

EP 4 562 187 A1

(12)

(43) Date of publication: 04.06.2025 Bulletin 2025/23 (21) Application number: 23847585.9 (22) Date of filing: 28.07.2023

(51) International Patent Classification (IPC):  C12Q 1/689(2018.01) C12M 1/34(2006.01) C12Q 1/686(2018.01) C12Q 1/6851(2018.01) C12Q 1/04(2006.01) C12Q 1/6888(2018.01) (52) Cooperative Patent Classification (CPC): C12Q 1/689; C12Q 1/6851; C12Q 1/6895 (86) International application number: PCT/US2023/071182 (87) International publication number: WO 2024/026440 (01.02.2024 Gazette 2024/05)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 29.07.2022 US 202263393550 P (71) Applicant: The Regents of The University of Michigan Ann Arbor, Michigan 48109-2590 (US)	(72) Inventors: BUGGA, Pallavi Ann Arbor, Michigan 48109-2590 (US) ASTHANA, Vishwaratn Ann Arbor, Michigan 48109-2590 (US) VANEPPS, Jeremy Scott Ann Arbor, Michigan 48109-2590 (US) MARTINEZ-NIEVES, Erika Ann Arbor, Michigan 48109-2590 (US) (74) Representative: Boult Wade Tennant LLP  Salisbury Square House 8 Salisbury Square London EC4Y 8AP London EC4Y 8AP (GB)