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EP 4 565 121 A1

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(43) Date of publication: 11.06.2025 Bulletin 2025/24 (21) Application number: 23850924.4 (22) Date of filing: 02.08.2023

(51) International Patent Classification (IPC):  A61B 5/00(2006.01) C07F 15/00(2006.01) A61K 49/00(2006.01) (52) Cooperative Patent Classification (CPC): C07F 15/006; G01N 33/004; G01N 33/52; G01N 2800/42; G01N 33/5308; C09K 11/06 (86) International application number: PCT/US2023/071492 (87) International publication number: WO 2024/030944 (08.02.2024 Gazette 2024/06)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 04.08.2022 US 202263395286 P (71) Applicant: Georgia State University Research Foundation, Inc. Atlanta, GA 30303 (US)	(72) Inventors: WANG, Binghe Atlanta, Georgia 30303 (US) YANG, Xiaoxiao Atlanta, Georgia 30303 (US) (74) Representative: Geling, Andrea  ZSP Patentanwälte PartG mbB Hansastraße 32 80686 München 80686 München (DE)