(19)
(11) EP 4 565 225 A2

(12)

(88) Date of publication A3:
11.04.2024

(43) Date of publication:
11.06.2025 Bulletin 2025/24

(21) Application number: 23850739.6

(22) Date of filing: 03.08.2023
(51) International Patent Classification (IPC): 
A61K 31/395(2006.01)
A61K 31/5513(2006.01)
A61K 31/40(2006.01)
A61K 31/33(2006.01)
(52) Cooperative Patent Classification (CPC):
C07D 487/04
(86) International application number:
PCT/US2023/029383
(87) International publication number:
WO 2024/030535 (08.02.2024 Gazette 2024/06)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA
Designated Validation States:
KH MA MD TN

(30) Priority: 03.08.2022 US 202263370329 P

(71) Applicants:
  • The Johns Hopkins University
    Baltimore, Maryland 21218 (US)
  • Lieber Institute, Inc.
    Baltimore, Maryland 21205 (US)

(72) Inventors:
  • BARROW, James C.
    Arnold, Maryland 21012 (US)
  • BUCHLER, Ingrid
    Baltimore, Maryland 21205 (US)
  • HUANG, Yifang
    Lansdale, Pennsylvania 19446 (US)
  • POSLUSNEY, Michael
    Baltimore, Maryland 21205 (US)
  • PASRICHA, Pankaj Jay
    Ellicott City, Maryland 21042 (US)

(74) Representative: Murgitroyd & Company 
165-169 Scotland Street
Glasgow G5 8PL
Glasgow G5 8PL (GB)

   


(54) PERIPHERALLY RESTRICTED GABA POSITIVE ALLOSTERIC MODULATORS FOR THE TREATMENT OF IRRITABLE BOWEL SYNDROME AND OTHER AILMENTS OF THE PERIPHERAL NERVOUS SYSTEM