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EP 4 565 227 A2

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(88) Date of publication A3: 07.03.2024 (43) Date of publication: 11.06.2025 Bulletin 2025/24 (21) Application number: 23850785.9 (22) Date of filing: 04.08.2023

(51) International Patent Classification (IPC):  A61K 31/395(2006.01) A61K 31/55(2006.01) A61K 31/18(2006.01) A61K 31/47(2006.01) A61K 31/551(2006.01) A61K 31/33(2006.01) (52) Cooperative Patent Classification (CPC): A61K 31/551; A61K 45/06; A61K 38/4833; A61K 38/57; C12Y 304/21005; A61K 38/1841; A61K 38/45; C12Y 203/02013; A61K 38/363; A61K 38/39; A61K 38/484; C12Y 304/21007   C-Sets: A61K 38/363, A61K 2300/00; A61K 38/39, A61K 2300/00; A61K 38/484, A61K 2300/00; A61K 38/4833, A61K 2300/00; A61K 38/57, A61K 2300/00; A61K 38/1841, A61K 2300/00; A61K 38/45, A61K 2300/00; (86) International application number: PCT/US2023/029495 (87) International publication number: WO 2024/030617 (08.02.2024 Gazette 2024/06)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 05.08.2022 US 202263395416 P (71) Applicants: Emory University Atlanta, Georgia 30322 (US) The United States Government as represented by the Department of Veterans Affairs Washington, DC 20420 (US)

(72) Inventors: PATEL, Jay M. Atlanta, Georgia 30322 (US) LABIB, Sameh A. Atlanta, Georgia 30322 (US) MYERS, David R. Atlanta, Georgia 30322 (US) HASSON, Maddie Atlanta, Georgia 30322 (US) FERNANDES, Lorenzo M. Atlanta, Georgia 30322 (US) (74) Representative: Coles, Andrea Birgit et al Kilburn & Strode LLP Lacon London 84 Theobalds Road London WC1X 8NL London WC1X 8NL (GB)