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(11)

EP 4 565 247 A1

(12)

(43) Date of publication: 11.06.2025 Bulletin 2025/24 (21) Application number: 23755033.0 (22) Date of filing: 04.08.2023

(51) International Patent Classification (IPC):  A61K 35/74(2015.01) C12N 1/20(2006.01) A61P 35/00(2006.01) (52) Cooperative Patent Classification (CPC): C12N 1/20; C12N 1/205; A61P 35/00; C12R 2001/01; A61K 35/741; A61K 2035/115 (86) International application number: PCT/EP2023/071660 (87) International publication number: WO 2024/028479 (08.02.2024 Gazette 2024/06)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 05.08.2022 EP 22189007 (71) Applicant: UNIVERSITE CATHOLIQUE DE LOUVAIN 1348 Louvain-la-Neuve (BE)	(72) Inventors: CANI, Patrice 1200 Bruxelles (BE) JORDAN, Bénédicte 1933 Sterrebeek (BE) MOENS DE HASE, Emilie 1180 Uccle (BE) YELEK, Caner 1140 Evere (BE) (74) Representative: Icosa  83 avenue Denfert-Rochereau 75014 Paris 75014 Paris (FR)