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EP 4 565 263 A2

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(88) Date of publication A3: 14.03.2024 (43) Date of publication: 11.06.2025 Bulletin 2025/24 (21) Application number: 23772756.5 (22) Date of filing: 02.08.2023

(51) International Patent Classification (IPC):  A61K 39/00(2006.01) C07K 14/725(2006.01) C07K 16/14(2006.01) A61P 35/00(2006.01) C12N 9/52(2006.01) C07K 16/28(2006.01) (52) Cooperative Patent Classification (CPC): A61P 35/00; C07K 14/7051; C07K 2319/03; C07K 2319/40; C07K 2319/90; C12Y 304/2207; C07K 16/14; C07K 2317/622; C12N 9/52; A61K 2239/24; A61K 2239/29; A61K 40/31; A61K 40/4201; A61K 40/42; A61K 40/4254; A61K 40/11 (86) International application number: PCT/CN2023/110768 (87) International publication number: WO 2024/027764 (08.02.2024 Gazette 2024/06)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 03.08.2022 WO PCT/CN2022/109857 (71) Applicants: Westlake Genetech. Ltd. Hangzhou, Zhejiang 310024 (CN) Westlake University Hangzhou, Zhejiang 310030 (CN)	(72) Inventors: LU, Zhike Hangzhou, Zhejiang 310030 (CN) MA, Lijia Hangzhou, Zhejiang 310030 (CN) NI, Ke Hangzhou, Zhejiang 310024 (CN) (74) Representative: Finnegan Europe LLP  1 London Bridge London SE1 9BG London SE1 9BG (GB)