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EP 4 565 281 A1

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(43) Date of publication: 11.06.2025 Bulletin 2025/24 (21) Application number: 23750999.7 (22) Date of filing: 31.07.2023

(51) International Patent Classification (IPC):  A61K 47/68(2017.01) A61P 35/00(2006.01) C07K 7/64(2006.01) A61K 47/64(2017.01) A61K 39/44(2006.01) (52) Cooperative Patent Classification (CPC): A61K 47/6889; A61K 47/6851; A61P 35/00; C07K 16/32; C07K 2317/24; C07K 16/2863; C07K 16/22; C07K 2319/33; A61K 39/44; C07K 7/08; A61K 47/64; A61K 47/68037 (86) International application number: PCT/EP2023/071199 (87) International publication number: WO 2024/028282 (08.02.2024 Gazette 2024/06)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 01.08.2022 EP 22382746 (71) Applicants: Gate2Brain, S.L. 08028 Barcelona (ES) Universitat de Barcelona 08028 Barcelona (ES) Fundació Institut de Recerca Biomèdica (IRB Barcelona) 08028 Barcelona (ES)

(72) Inventors: SÁNCHEZ NAVARRO, Macarena 08028 Barcelona (ES) TEIXIDÓ TURÀ, Meritxell 08028 Barcelona (ES) GIRALT LLEDÓ, Ernest 08028 Barcelona (ES) (74) Representative: ZBM Patents - Zea, Barlocci & Markvardsen  Rambla de Catalunya, 123 08008 Barcelona 08008 Barcelona (ES)