(19)

(11)

EP 4 565 615 A2

(12)

(88) Date of publication A3: 04.04.2024 (43) Date of publication: 11.06.2025 Bulletin 2025/24 (21) Application number: 23850893.1 (22) Date of filing: 01.08.2023

(51) International Patent Classification (IPC):  C07K 16/28(2006.01) A61P 29/00(2006.01) G01N 33/566(2006.01) A61K 39/395(2006.01) C12N 15/85(2006.01) G01N 33/53(2006.01) (52) Cooperative Patent Classification (CPC): C07K 16/2878; C07K 2317/76; C07K 2317/52; C07K 2317/71; C07K 2317/94; C07K 2317/24 (86) International application number: PCT/US2023/071404 (87) International publication number: WO 2024/030888 (08.02.2024 Gazette 2024/06)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 01.08.2022 US 202263394057 P 07.11.2022 US 202263423223 P (71) Applicant: Yale University New Haven, CT 06510 (US)	(72) Inventor: JOHNSON, Raymond New Haven, Connecticut 06511 (US) (74) Representative: Bassil, Nicholas Charles et al Kilburn & Strode LLP Lacon London 84 Theobalds Road London WC1X 8NL London WC1X 8NL (GB)