(19)
(11) EP 4 565 692 A2

(12)

(88) Date of publication A3:
25.04.2024

(43) Date of publication:
11.06.2025 Bulletin 2025/24

(21) Application number: 23851018.4

(22) Date of filing: 04.08.2023
(51) International Patent Classification (IPC): 
C12N 15/09(2006.01)
C12N 15/85(2006.01)
 C07K 14/005(2006.01)
C12N 15/67(2006.01)
(52) Cooperative Patent Classification (CPC):
C12N 15/67; C12N 2840/203; C12N 15/85; C12N 2840/60
(86) International application number:
PCT/US2023/071742
(87) International publication number:
WO 2024/031087 (08.02.2024 Gazette 2024/06)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA
Designated Validation States:
KH MA MD TN

(30) Priority: 05.08.2022 US 202263395614 P

(71) Applicant: ModernaTX, Inc.
Cambridge, MA 02139 (US)

(72) Inventors:
  • JAIN, Ruchi
    Cambridge, MA 02139 (US)
  • METKAR, Mihir
    Cambridge, MA 02139 (US)
  • ANDRIANOVA, Elizaveta
    Cambridge, MA 02139 (US)

(74) Representative: Hoffmann Eitle 
Patent- und Rechtsanwälte PartmbB Arabellastraße 30
81925 München
81925 München (DE)

   


(54) INTERNAL RIBOSOME ENTRY SITES FOR IMPROVED POLYNUCLEOTIDE TRANSLATION