(19)

(11)

EP 4 565 705 A2

(12)

(88) Date of publication A3: 18.04.2024 (43) Date of publication: 11.06.2025 Bulletin 2025/24 (21) Application number: 23850920.2 (22) Date of filing: 01.08.2023

(51) International Patent Classification (IPC):  C12N 15/86(2006.01) A61K 35/761(2015.01) C12N 5/0793(2010.01) A61K 35/30(2015.01) A61K 38/17(2006.01) (52) Cooperative Patent Classification (CPC): C12N 15/86; C12N 2750/14143; A61P 27/02; A61K 48/0075; A61K 48/005; A61K 38/00; A61K 48/0058; C07K 14/4702 (86) International application number: PCT/US2023/071472 (87) International publication number: WO 2024/030930 (08.02.2024 Gazette 2024/06)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 01.08.2022 US 202263394065 P (71) Applicant: The Johns Hopkins University Baltimore, MD 21218 (US)	(72) Inventors: BLACKSHAW, Seth Baltimore, MD 21205 (US) HOANG, Thanh Baltimore, MD 21218 (US) (74) Representative: CH Kilger Anwaltspartnerschaft mbB  Fasanenstraße 29 10719 Berlin 10719 Berlin (DE)