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EP 4 565 706 A1

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(43) Date of publication: 11.06.2025 Bulletin 2025/24 (21) Application number: 23850805.5 (22) Date of filing: 04.08.2023

(51) International Patent Classification (IPC):  C12P 7/62(2022.01) C12P 1/04(2006.01) C12N 15/09(2006.01) C12N 5/10(2006.01) C07H 17/08(2006.01) C12P 17/06(2006.01) C12N 15/52(2006.01) C12P 21/02(2006.01) (52) Cooperative Patent Classification (CPC): C12P 17/06; C12Y 301/02; C12Y 203/01; C12Y 101/01; C12N 15/70 (86) International application number: PCT/US2023/029574 (87) International publication number: WO 2024/030662 (08.02.2024 Gazette 2024/06)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 05.08.2022 US 202263395739 P (71) Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA Oakland, CA 94607-5200 (US)	(72) Inventors: HAUSHALTER, Robert Oakland, California 94607-5200 (US) WANG, Zilong Oakland, California 94607-5200 (US) CHEONG, Seokjung Oakland, California 94607-5200 (US) KEASLING, Jay Oakland, California 94607-5200 (US) (74) Representative: J A Kemp LLP  80 Turnmill Street London EC1M 5QU London EC1M 5QU (GB)