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(11)

EP 4 568 652 A1

(12)

(43) Date of publication: 18.06.2025 Bulletin 2025/25 (21) Application number: 23783094.8 (22) Date of filing: 11.09.2023

(51) International Patent Classification (IPC):  A61K 9/00(2006.01) A61K 9/127(2025.01) A61K 31/045(2006.01) A61K 31/07(2006.01) A61K 31/19(2006.01) A61K 31/20(2006.01) A61K 31/355(2006.01) A61K 31/385(2006.01) A61K 31/522(2006.01) A61K 31/60(2006.01) A61K 31/7034(2006.01) A61K 8/34(2006.01) A61K 31/015(2006.01) A61K 31/05(2006.01) A61K 31/167(2006.01) A61K 31/192(2006.01) A61K 31/203(2006.01) A61K 31/375(2006.01) A61K 31/455(2006.01) A61K 31/593(2006.01) A61K 31/685(2006.01) (52) Cooperative Patent Classification (CPC): A61K 9/0014; A61K 47/10; A61K 9/1272; A61Q 19/00; A61K 45/06; A61K 31/658; A61K 8/14; A61K 8/342; A61K 8/31; A61K 8/498; A61K 8/602; A61K 8/345; A61K 8/20; A61Q 19/08; A61K 31/365   C-Sets: A61K 31/658, A61K 2300/00; A61K 31/365, A61K 2300/00; (86) International application number: PCT/IL2023/050976 (87) International publication number: WO 2024/057304 (21.03.2024 Gazette 2024/12)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 12.09.2022 US 202263405665 P (71) Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. 9139002 Jerusalem (IL)	(72) Inventors: TOUITOU, Elka 3090939 Zichron Yaacov (IL) NATSHEH, Hiba 9701627 Jerusalem (IL) (74) Representative: Potter Clarkson  Chapel Quarter Mount Street Nottingham NG1 6HQ Nottingham NG1 6HQ (GB)