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EP 4 568 705 A2

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(88) Date of publication A3: 28.03.2024 (43) Date of publication: 18.06.2025 Bulletin 2025/25 (21) Application number: 23853505.8 (22) Date of filing: 09.08.2023

(51) International Patent Classification (IPC):  A61K 47/42(2017.01) C08J 3/075(2006.01) A61L 27/54(2006.01) C01B 33/20(2006.01) A61L 27/52(2006.01) A61M 25/00(2006.01) (52) Cooperative Patent Classification (CPC): A61B 2017/00707; A61B 2017/00725; A61B 17/1219; A61B 17/12113; A61B 2017/00893; G09B 23/28; A61B 2017/00526; A61L 2400/06; A61L 2400/12; A61L 2430/36; A61L 24/0089; A61L 24/001; A61L 24/0015; A61L 27/446; A61L 27/50; A61L 27/54   C-Sets: A61L 24/0089, C08L 89/06; A61L 27/446, C08L 89/06; (86) International application number: PCT/US2023/071909 (87) International publication number: WO 2024/036198 (15.02.2024 Gazette 2024/07)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 09.08.2022 US 202263396367 P (71) Applicants: The Regents of University of California Oakland, CA 94607-5200 (US) The Penn State Research Foundation University Park, PA 16802-7000 (US)

(72) Inventors: SHEIKHI, Amir State College, Pennsylvania 16801 (US) BAIDYA, Avijit Los Angeles, California 90034 (US) KHADEMHOSSEINI, Alireza Los Angeles, California 90049 (US) (74) Representative: Murgitroyd & Company  165-169 Scotland Street Glasgow G5 8PL Glasgow G5 8PL (GB)