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EP 4 568 948 A1

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(43) Date of publication: 18.06.2025 Bulletin 2025/25 (21) Application number: 23783180.5 (22) Date of filing: 11.09.2023

(51) International Patent Classification (IPC):  C07D 239/42(2006.01) C07D 401/14(2006.01) C07D 403/14(2006.01) C07D 409/12(2006.01) C07D 417/12(2006.01) C07D 487/04(2006.01) A61K 31/505(2006.01) A61P 35/00(2006.01) C07D 401/12(2006.01) C07D 403/12(2006.01) C07D 405/12(2006.01) C07D 413/12(2006.01) C07D 471/04(2006.01) C07D 513/04(2006.01) A61K 31/506(2006.01) (52) Cooperative Patent Classification (CPC): C07D 239/42; C07D 403/12; C07D 401/12; C07D 401/14; C07D 471/04; C07D 487/04; C07D 513/04; C07D 417/12; C07D 413/12; C07D 409/12; C07D 403/14; C07D 405/12 (86) International application number: PCT/US2023/032420 (87) International publication number: WO 2024/059010 (21.03.2024 Gazette 2024/12)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 13.09.2022 US 202263406081 P 26.10.2022 US 202263419451 P 23.12.2022 US 202263435170 P 01.09.2023 US 202363536249 P (71) Applicant: Genesis Therapeutics, Inc. Burlingame, California 94010 (US)

(72) Inventors: NAGLE, Advait Burlingame, California 94010 (US) STOCK, Nicholas Simon Burlingame, California 94010 (US) SWIDERSKI, Wojciech Piotr Burlingame, California 94010 (US) FEINBERG, Evan Nathaniel Burlingame, California 94010 (US) SKLAROFF, Ben Burlingame, California 94010 (US) REINUS, Brandon Burlingame, California 94010 (US) MCALPINE, Indrawan Burlingame, California 94010 (US) INDARTE, Martin Burlingame, California 94010 (US) BURKE, Christopher P. Burlingame, California 94010 (US) NAGAMIZO, Joe Fred Burlingame, California 94010 (US) VAN VENROOY, Alexis Burlingame, California 94010 (US) (74) Representative: Fish & Richardson P.C.  Highlight Business Towers Mies-van-der-Rohe-Straße 8 80807 München 80807 München (DE)