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EP 4 568 969 A1

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(43) Date of publication: 18.06.2025 Bulletin 2025/25 (21) Application number: 23761737.8 (22) Date of filing: 07.08.2023

(51) International Patent Classification (IPC):  C07D 491/22(2006.01) A61P 35/00(2006.01) A61K 31/4192(2006.01) (52) Cooperative Patent Classification (CPC): C07D 491/22 (86) International application number: PCT/US2023/071759 (87) International publication number: WO 2024/036098 (15.02.2024 Gazette 2024/07)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 12.08.2022 US 202263397674 P (71) Applicant: Nuvalent, Inc. Cambridge, MA 02142 (US)	(72) Inventors: HORAN, Joshua, Courtney Cambridge, MA 02142 (US) SOGLIA, John, R. Cambridge, MA 02142 (US) (74) Representative: Jones Day  Rechtsanwälte, Attorneys-at-Law, Patentanwälte Gewürzmühlstraße 11 80538 München 80538 München (DE)