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EP 4 568 972 A1

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(43) Date of publication: 18.06.2025 Bulletin 2025/25 (21) Application number: 23753891.3 (22) Date of filing: 07.08.2023

(51) International Patent Classification (IPC):  C07D 498/04(2006.01) A61P 11/00(2006.01) C07D 519/00(2006.01) A61K 31/5365(2006.01) (52) Cooperative Patent Classification (CPC): C07D 519/00; C07D 498/04; A61P 11/00 (86) International application number: PCT/EP2023/071758 (87) International publication number: WO 2024/033277 (15.02.2024 Gazette 2024/07)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 08.08.2022 EP 22189168 31.05.2023 EP 23176294 (71) Applicant: F. Hoffmann-La Roche AG 4070 Basel (CH)

(72) Inventors: BENZ, Joerg 4070 Basel (CH) GIROUD, Maude 4070 Basel (CH) GRETHER, Uwe Michael 4070 Basel (CH) KUHN, Bernd 4070 Basel (CH) LELKE, Alina 4070 Basel (CH) O'HARA, Fionn Susannah 4070 Basel (CH) RITTER, Martin 4070 Basel (CH) ROMBACH, Didier 4070 Basel (CH) SCHMID, Philipp Claudio 4070 Basel (CH) WITTWER, Matthias Beat 4070 Basel (CH) (74) Representative: Neuhaus, Christian Michel  F. Hoffmann-La Roche AG Grenzacherstrasse 124 4070 Basel 4070 Basel (CH)