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EP 4 568 998 A1

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(43) Date of publication: 18.06.2025 Bulletin 2025/25 (21) Application number: 23853151.1 (22) Date of filing: 07.08.2023

(51) International Patent Classification (IPC):  C07K 16/28(2006.01) G01N 33/563(2006.01) A61K 39/395(2006.01) A61P 35/00(2006.01) (52) Cooperative Patent Classification (CPC): A61P 35/00; C07K 16/2878; C07K 2317/22; C07K 2317/569; C07K 2317/33; C07K 2317/73; C07K 2317/92; A61K 2039/505; A61K 40/11; A61K 40/31; A61K 40/4224 (86) International application number: PCT/SG2023/050545 (87) International publication number: WO 2024/035342 (15.02.2024 Gazette 2024/07)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 08.08.2022 US 202263396110 P (71) Applicants: Tikva allocell Pte. Ltd. Singapore 138673 (SG) Agency for Science, Technology and Research Singapore 138632 (SG)

(72) Inventors: LOW, Lionel Jianrong Singapore 098633 (SG) TAN, Kar Wai Singapore 098633 (SG) YEO, Siok Ping Singapore 098633 (SG) KOH, Xinyu Singapore 098633 (SG) KUA, Lindsay, Hsien Pin Singapore 098633 (SG) (74) Representative: Mewburn Ellis LLP  Aurora Building Counterslip Bristol BS1 6BX Bristol BS1 6BX (GB)