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EP 4 568 999 A1

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(43) Date of publication: 18.06.2025 Bulletin 2025/25 (21) Application number: 23853152.9 (22) Date of filing: 07.08.2023

(51) International Patent Classification (IPC):  C07K 16/28(2006.01) A61P 35/00(2006.01) A61K 39/395(2006.01) A61P 37/06(2006.01) (52) Cooperative Patent Classification (CPC): A61P 35/00; A61P 37/06; C07K 16/2878; C07K 2317/622; A61K 2039/505; A61K 2239/17; C07K 14/7051; C07K 14/70521; C07K 2319/03; A61K 40/11; A61K 40/31; A61K 40/4224 (86) International application number: PCT/SG2023/050546 (87) International publication number: WO 2024/035343 (15.02.2024 Gazette 2024/07)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 08.08.2022 US 202263396156 P (71) Applicants: Tikva allocell Pte. Ltd. Singapore 138673 (SG) Agency for Science, Technology and Research Singapore 138632 (SG)

(72) Inventors: LOW, Lionel Jianrong Singapore 098633 (SG) TAN, Kar Wai Singapore 098633 (SG) NG, Chee Hoe Singapore 098633 (SG) TAN, Jin Wei Singapore 098633 (SG) (74) Representative: Mewburn Ellis LLP  Aurora Building Counterslip Bristol BS1 6BX Bristol BS1 6BX (GB)