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EP 4 569 110 A2

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(88) Date of publication A3: 21.03.2024 (43) Date of publication: 18.06.2025 Bulletin 2025/25 (21) Application number: 23755360.7 (22) Date of filing: 10.08.2023

(51) International Patent Classification (IPC):  C12N 15/113(2010.01) A61P 21/00(2006.01) A61K 31/713(2006.01) (52) Cooperative Patent Classification (CPC): C12N 15/1137; C12N 2310/14; C12N 2320/34 (86) International application number: PCT/EP2023/072157 (87) International publication number: WO 2024/033467 (15.02.2024 Gazette 2024/07)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 11.08.2022 EP 22306213 (71) Applicants: Institut National de la Santé et de la Recherche Médicale 75013 Paris (FR) Sorbonne Université 75006 Paris (FR) Association Institut de Myologie 75013 Paris (FR)

(72) Inventors: BITOUN, Marc 75651 Paris Cedex 13 (FR) TROCHET, Delphine 75651 Paris Cedex 13 (FR) (74) Representative: Inserm Transfert  PariSanté Campus 10 rue d'Oradour-sur-Glane 75015 Paris 75015 Paris (FR)