(19)

(11)

EP 4 569 116 A2

(12)

(88) Date of publication A3: 16.05.2024 (43) Date of publication: 18.06.2025 Bulletin 2025/25 (21) Application number: 23853497.8 (22) Date of filing: 09.08.2023

(51) International Patent Classification (IPC):  C12N 15/113(2010.01) A61K 31/7125(2006.01) A61P 25/28(2006.01) A61K 31/7088(2006.01) A61K 9/00(2006.01) (52) Cooperative Patent Classification (CPC): A61K 31/712; C12N 15/113; C12N 2310/11; C12N 2320/34; C12N 2310/341; C12N 2310/3231; C12N 2310/315   C-Sets: C12N 2310/321, C12N 2310/3525; (86) International application number: PCT/US2023/071895 (87) International publication number: WO 2024/036186 (15.02.2024 Gazette 2024/07)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 09.08.2022 US 202263396545 P (71) Applicant: The University of Massachusetts Boston, MA 02108 (US)	(72) Inventors: LANDERS, John Edward Natick, Massachusetts 01760 (US) POWELL, Desiree Marie Northborough, Massachusetts 01532 (US) (74) Representative: Haseltine Lake Kempner LLP  One Portwall Square Portwall Lane Bristol BS1 6BH Bristol BS1 6BH (GB)