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EP 4 572 747 A1

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(43) Date of publication: 25.06.2025 Bulletin 2025/26 (21) Application number: 23855286.3 (22) Date of filing: 15.06.2023

(51) International Patent Classification (IPC):  A61K 31/015(2006.01) A61K 31/135(2006.01) A61K 31/03(2006.01) A61K 31/12(2006.01) (52) Cooperative Patent Classification (CPC): A61K 31/216; C07C 69/16; C07C 2602/44 (86) International application number: PCT/US2023/025444 (87) International publication number: WO 2024/039435 (22.02.2024 Gazette 2024/08)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 19.08.2022 US 202263399312 P (71) Applicants: Florida Atlantic University Board Of Trustees Boca Raton, FL 33434 (US) Nova Southeastern University Fort Lauderdale, FL 33314 (US)

(72) Inventors: LEPORE, Salvatore D. Delray Beach, Florida 33445 (US) STILLEY, Samantha E. Tequesta, Florida 33469 (US) YADAVALLI, Krishna Lafayette, Florida 47905 (US) DAWSON-SCULLY, Ken Boca Raton, Florida 33496 (US) (74) Representative: Sandvoß, Stefanie  Patentanwaltskanzlei Sandvoß Dethmarstraße 44a 31139 Hildesheim 31139 Hildesheim (DE)