(19)

(11)

EP 4 572 775 A2

(12)

(88) Date of publication A3: 25.04.2024 (43) Date of publication: 25.06.2025 Bulletin 2025/26 (21) Application number: 23855611.2 (22) Date of filing: 15.08.2023

(51) International Patent Classification (IPC):  A61K 35/17(2025.01) A61P 37/06(2006.01) A61P 35/00(2006.01) C12N 5/0783(2010.01) C12N 5/10(2006.01) A61K 35/15(2025.01) (52) Cooperative Patent Classification (CPC): A61K 35/17; A61P 37/06; A61K 40/15; A61K 40/22; A61K 40/32; A61K 40/50 (86) International application number: PCT/US2023/072223 (87) International publication number: WO 2024/040061 (22.02.2024 Gazette 2024/08)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 16.08.2022 US 202263398408 P (71) Applicant: The Regents of University of California Oakland, CA 94607-5200 (US)	(72) Inventors: YANG, Lili Los Angeles, California 90024 (US) LI, Yan-Ruide North Hills, California 91343 (US) (74) Representative: Murgitroyd & Company  165-169 Scotland Street Glasgow G5 8PL Glasgow G5 8PL (GB)