(19)

(11)

EP 4 572 785 A1

(12)

(43) Date of publication: 25.06.2025 Bulletin 2025/26 (21) Application number: 23768048.3 (22) Date of filing: 15.08.2023

(51) International Patent Classification (IPC):  A61K 39/00(2006.01) C07K 16/28(2006.01) (52) Cooperative Patent Classification (CPC): C07K 16/28; A61K 2039/505; C07K 2317/622; C07K 2317/24; C07K 2317/565; A61K 39/00; C07K 2317/33 (86) International application number: PCT/US2023/030265 (87) International publication number: WO 2024/039670 (22.02.2024 Gazette 2024/08)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 15.08.2022 US 202263398075 P (71) Applicant: Dana-Farber Cancer Institute, Inc. Boston, Massachusetts 02215 (US)	(72) Inventors: MARASCO, Wayne A. Boston, Massachusetts 02214 (US) CHANG, Matthew Boston, Massachusetts 02214 (US) (74) Representative: Barker Brettell LLP  100 Hagley Road Edgbaston Birmingham B16 8QQ Birmingham B16 8QQ (GB)