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EP 4 573 095 A1

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(43) Date of publication: 25.06.2025 Bulletin 2025/26 (21) Application number: 23769053.2 (22) Date of filing: 16.08.2023

(51) International Patent Classification (IPC):  C07D 471/22(2006.01) A61P 35/00(2006.01) C07D 498/22(2006.01) A61K 31/519(2006.01) (52) Cooperative Patent Classification (CPC): C07D 471/22; C07D 498/22; A61P 35/00 (86) International application number: PCT/US2023/072332 (87) International publication number: WO 2024/040131 (22.02.2024 Gazette 2024/08)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 17.08.2022 US 202263398737 P 21.11.2022 US 202263426885 P 31.03.2023 US 202363456316 P 13.07.2023 US 202363526503 P (71) Applicant: Treeline Biosciences, Inc. Watertown, Massachusetts 02472 (US)

(72) Inventors: LAJINESS, James Paul San Diego, California 92121 (US) GIANATASSIO, Ryan L. San Diego, California 92121 (US) MARRONE, Tami J. San Diego, California 92121 (US) MCCLYMONT, Kyle Stephen San Diego, California 92121 (US) VALIERE, Andrew San Diego, California 92121 (US) (74) Representative: Fish & Richardson P.C.  Highlight Business Towers Mies-van-der-Rohe-Straße 8 80807 München 80807 München (DE)