(19)

(11)

EP 4 573 371 A2

(12)

(88) Date of publication A3: 28.03.2024 (43) Date of publication: 25.06.2025 Bulletin 2025/26 (21) Application number: 23855713.6 (22) Date of filing: 18.08.2023

(51) International Patent Classification (IPC):  G01N 33/68(2006.01) G01N 33/50(2006.01) G01N 33/487(2006.01) (52) Cooperative Patent Classification (CPC): G01N 2800/347; G01N 33/6893; G01N 2800/60; G01N 2800/52; G01N 2800/50; G01N 33/5014; C12Q 1/6883; C12Q 2600/158 (86) International application number: PCT/US2023/072477 (87) International publication number: WO 2024/040225 (22.02.2024 Gazette 2024/08)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 19.08.2022 US 202263371894 P (71) Applicant: The Johns Hopkins University Baltimore, Maryland 21218 (US)	(72) Inventors: PARIKH, Chirag Lutherville, Maryland 21093 (US) WEN, Yumeng Baltimore, Maryland 21287 (US) (74) Representative: Murgitroyd & Company  165-169 Scotland Street Glasgow G5 8PL Glasgow G5 8PL (GB)