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(11)

EP 4 577 233 A1

(12)

(43) Date of publication: 02.07.2025 Bulletin 2025/27 (21) Application number: 23764369.7 (22) Date of filing: 22.08.2023

(51) International Patent Classification (IPC):  A61K 39/00(2006.01) A61P 35/00(2006.01) (52) Cooperative Patent Classification (CPC): A61P 35/00; A61K 2239/48; A61K 40/15; A61K 40/11; A61K 40/31; A61K 40/421; A61K 40/50 (86) International application number: PCT/GB2023/052187 (87) International publication number: WO 2024/042318 (29.02.2024 Gazette 2024/09)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 23.08.2022 GR 20220100703 (71) Applicant: Imperial College Innovations Limited London SW7 2AZ (GB)	(72) Inventors: KARADIMITRIS, Anastasios London SW7 2AZ (GB) ROWAN, Aileen London SW7 2AZ (GB) (74) Representative: Hutter, Anton et al Venner Shipley LLP 5 Stirling House Stirling Road The Surrey Research Park Guildford GU2 7RF Guildford GU2 7RF (GB)