(19)
(11) EP 4 577 248 A1

(12)

(43) Date of publication:
02.07.2025 Bulletin 2025/27

(21) Application number: 23764257.4

(22) Date of filing: 26.08.2023
(51) International Patent Classification (IPC): 
A61K 47/68(2017.01)
 A61P 35/00(2006.01)
(52) Cooperative Patent Classification (CPC):
A61K 47/6829; A61K 47/6831; A61P 35/00
(86) International application number:
PCT/EP2023/073456
(87) International publication number:
WO 2024/046929 (07.03.2024 Gazette 2024/10)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA
Designated Validation States:
KH MA MD TN

(30) Priority: 27.08.2022 EP 22192517

(71) Applicant: Simris Biologics GmbH
12489 Berlin (DE)

(72) Inventors:
  • ENKE, Heike
    12307 Berlin (DE)
  • ENKE, Dan
    12307 Berlin (DE)
  • NIEDERMEYER, Timo
    06114 Halle (Saale) (DE)
  • STOCK, Laura
    06112 Halle (Saale) (DE)
  • SCHUSTER, Sabine
    06120 Halle (DE)

(74) Representative: Andresen, Heiko 
Hansepatent Patentanwälte Andresen Scholz PartG mbB Poststraße 33
20354 Hamburg
20354 Hamburg (DE)

   


(54) A METHOD OF MODIFYING AN ORGANIC CYTOTOXIN FOR USE AS A PAYLOAD IN AN ANTIBODY-DRUG CONJUGATE AND MODIFIED ORGANIC CYTOTOXINS DERIVED THEREFROM