(19)

(11)

EP 4 577 306 A1

(12)

(43) Date of publication: 02.07.2025 Bulletin 2025/27 (21) Application number: 23761808.7 (22) Date of filing: 23.08.2023

(51) International Patent Classification (IPC):  A61P 35/00(2006.01) C07K 16/28(2006.01) (52) Cooperative Patent Classification (CPC): C07K 16/2878; C07K 2317/75; C07K 2317/76; A61K 2039/505; A61K 2039/507; C07K 2317/31; A61P 35/00 (86) International application number: PCT/EP2023/073074 (87) International publication number: WO 2024/042104 (29.02.2024 Gazette 2024/09)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 26.08.2022 US 202263401290 P (71) Applicant: Merck Patent GmbH 64293 Darmstadt (DE)	(72) Inventor: XU, Chunxiao Billerica, MA 01821-3936 (US) (74) Representative: Merck Patent Association  Merck Patent GmbH 64271 Darmstadt 64271 Darmstadt (DE)