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(11)

EP 4 577 308 A2

(12)

(88) Date of publication A3: 16.05.2024 (43) Date of publication: 02.07.2025 Bulletin 2025/27 (21) Application number: 23858267.0 (22) Date of filing: 23.08.2023

(51) International Patent Classification (IPC):  A61P 35/00(2006.01) A61K 9/14(2006.01) A01N 59/16(2006.01) A61K 47/69(2017.01) A61K 31/7076(2006.01) (52) Cooperative Patent Classification (CPC): A61K 47/6923; A61K 47/6929; B82Y 5/00 (86) International application number: PCT/US2023/072735 (87) International publication number: WO 2024/044636 (29.02.2024 Gazette 2024/09)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 24.08.2022 US 202263373409 P (71) Applicant: The Board of Trustees of The Leland Stanford Junior University Stanford, California 94305-2038 (US)	(72) Inventors: BEKALE, Laurent Redwood City, CA 94063 (US) SANTA-MARIA, Peter Luke Emerald Hills, CA 94062 (US) (74) Representative: Bassil, Nicholas Charles et al Kilburn & Strode LLP Lacon London 84 Theobalds Road London WC1X 8NL London WC1X 8NL (GB)