(19)

(11)

EP 4 577 524 A1

(12)

(43) Date of publication: 02.07.2025 Bulletin 2025/27 (21) Application number: 23856644.2 (22) Date of filing: 23.08.2023

(51) International Patent Classification (IPC):  C07D 233/90(2006.01) C07D 403/04(2006.01) C07D 405/04(2006.01) (52) Cooperative Patent Classification (CPC): C07D 405/04; C07D 233/90; C07D 401/04; C07D 403/14 (86) International application number: PCT/CN2023/114387 (87) International publication number: WO 2024/041555 (29.02.2024 Gazette 2024/09)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 24.08.2022 WO PCT/CN2022/114447 (71) Applicant: Insilico Medicine IP Limited Central, Hong Kong (HK)	(72) Inventors: LIANG, Xing Shanghai 201203 (CN) CAO, Hua Shanghai 201203 (CN) CHENG, Xin Shanghai 201203 (CN) QIN, Luoheng Shanghai 201203 (CN) (74) Representative: Mewburn Ellis LLP  Aurora Building Counterslip Bristol BS1 6BX Bristol BS1 6BX (GB)