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(11)

EP 4 577 537 A1

(12)

(43) Date of publication: 02.07.2025 Bulletin 2025/27 (21) Application number: 23757923.0 (22) Date of filing: 21.08.2023

(51) International Patent Classification (IPC):  C07D 403/12(2006.01) C07D 413/14(2006.01) C07D 487/04(2006.01) A61K 31/4985(2006.01) C07D 413/12(2006.01) C07D 471/04(2006.01) C07D 495/04(2006.01) A61P 35/00(2006.01) (52) Cooperative Patent Classification (CPC): C07D 413/12; C07D 403/12; C07D 487/04; C07D 471/04; C07D 413/14; C07D 495/04; A61P 35/00 (86) International application number: PCT/EP2023/072876 (87) International publication number: WO 2024/042007 (29.02.2024 Gazette 2024/09)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 23.08.2022 EP 22191702 (71) Applicant: Merck Patent GmbH 64293 Darmstadt (DE)	(72) Inventors: BUCHSTALLER, Hans-Peter 64293 DARMSTADT (DE) KUHN, Daniel 64293 Darmstadt (DE) COLLINS, Ian London SW73RP (GB) MATTHEWS, Thomas London SW73RP (GB) LANZ, Jan London SW73RP (GB) SAINT-DIZIER, François London SW73RP (GB) PREVET, Hugues London SW73RP (GB) (74) Representative: Merck Patent Association  Merck Patent GmbH 64271 Darmstadt 64271 Darmstadt (DE)