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(11)

EP 4 577 557 A1

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(43) Date of publication: 02.07.2025 Bulletin 2025/27 (21) Application number: 23733931.2 (22) Date of filing: 16.06.2023

(51) International Patent Classification (IPC):  C07K 14/135(2006.01) A61K 39/12(2006.01) C12N 15/40(2006.01) (52) Cooperative Patent Classification (CPC): C07K 14/005; A61K 39/12; C07K 2319/02; C07K 2319/03; C12N 2760/18522; C12N 2760/18534; A61K 2039/55572; A61K 2039/55577; A61K 2039/575; A61K 2039/53; A61K 2039/55555; C12N 2760/18571; A61P 31/14 (86) International application number: PCT/EP2023/066332 (87) International publication number: WO 2024/041773 (29.02.2024 Gazette 2024/09)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 22.08.2022 US 202263399804 P 22.08.2022 US 202263399811 P 22.12.2022 US 202263476694 P 22.12.2022 US 202263476696 P 10.02.2023 EP 23155959 10.02.2023 EP 23155964 17.03.2023 US 202363452728 P 17.03.2023 US 202363452760 P 17.03.2023 US 202363452793 P (71) Applicant: GlaxoSmithKline Biologicals S.A. 1330 Rixensart (BE)

(72) Inventors: BARROWS, Nicholas John Rockville, Maryland 20850 (US) BIANCUCCI, Marco Rockville, Maryland 20850 (US) CHESTERMAN, Chelsy Caryn Rockville, Maryland 20850 (US) HARSHBARGER, Wayne Daniel Rockville, Maryland 20850 (US) MOUSAVI, Kambiz Rockville, Maryland 20850 (US) WAHOME, Newton Muchugu Rockville, Maryland 20850 (US) WANG, Xiaofeng Rockville, Maryland 20850 (US) WILLIAMS, James Alan Rockville, Maryland 20850 (US) MALLETT, Corey Rockville, Maryland 20850 (US) PHOGAT, Sanjay Rockville, Maryland 20850 (US) HOLZAPFEL, Genevieve Rockville, Maryland 20850 (US) PHUNG, Emily Rockville, Maryland 20850 (US) (74) Representative: West, Heloise  GSK Legal & Compliance - Global Patents 79 New Oxford Street London WC1A 1DG London WC1A 1DG (GB)