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EP 4 577 562 A1

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(43) Date of publication: 02.07.2025 Bulletin 2025/27 (21) Application number: 23761879.8 (22) Date of filing: 25.08.2023

(51) International Patent Classification (IPC):  C07K 14/47(2006.01) A61K 39/00(2006.01) C07K 14/725(2006.01) C07K 14/74(2006.01) A61P 37/02(2006.01) (52) Cooperative Patent Classification (CPC): C07K 14/4748; C07K 14/70539; A61P 37/02; C07K 14/7051; A61K 40/11; A61K 40/4268 (86) International application number: PCT/EP2023/073331 (87) International publication number: WO 2024/042202 (29.02.2024 Gazette 2024/09)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 26.08.2022 EP 22192464 (71) Applicant: Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft 13125 Berlin (DE)	(72) Inventors: LORENZ, Felix 13129 Berlin (DE) CLAUSS, Julian 13086 Berlin (DE) EDES, Inan 13156 Berlin (DE) STAHN, Rainer 13125 Berlin (DE) SADA JAPP, Alberto 10439 Berlin (DE) HILGENBERG, Ellen 10439 Berlin (DE) UCKERT, Wolfgang 13125 Berlin (DE) (74) Representative: Moré, Solveig Helga  Kroher Strobel Rechts- und Patentanwälte PartmbB Bavariaring 20 80336 München 80336 München (DE)