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(11)

EP 4 577 568 A2

(12)

(88) Date of publication A3: 04.04.2024 (43) Date of publication: 02.07.2025 Bulletin 2025/27 (21) Application number: 23858316.5 (22) Date of filing: 24.08.2023

(51) International Patent Classification (IPC):  C07K 16/18(2006.01) A61P 35/00(2006.01) A61K 47/68(2017.01) (52) Cooperative Patent Classification (CPC): C07K 16/44; C07K 2317/24; C07K 2317/565; C07K 2317/622; C07K 2317/55; C07K 2319/31 (86) International application number: PCT/US2023/072852 (87) International publication number: WO 2024/044709 (29.02.2024 Gazette 2024/09)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 24.08.2022 US 202263373367 P 21.08.2023 US 202363520689 P (71) Applicant: The Research Foundation for The State University of New York Amherst, NY 14228-2577 (US)

(72) Inventors: BALTHASAR, Joseph, P. Lancaster, NY 14086 (US) BORDEAU, Brandon, M. West Seneca, NY 14224 (US) NGUYEN, Toan, Duc Williamsville, NY 14221 (US) POLLI, Joseph, Ryan Cambridge, MA 02139 (US) (74) Representative: FRKelly  Waterways House Grand Canal Quay Dublin D02 PD39 Dublin D02 PD39 (IE)