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EP 4 577 650 A1

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(43) Date of publication: 02.07.2025 Bulletin 2025/27 (21) Application number: 23767974.1 (22) Date of filing: 25.08.2023

(51) International Patent Classification (IPC):  C12N 15/11(2006.01) C12N 15/113(2010.01) C12N 9/22(2006.01) C12N 5/0783(2010.01) (52) Cooperative Patent Classification (CPC): C12N 15/111; C12N 15/1138; C12N 2310/20; C12N 2310/315; C12N 2310/3231; C12N 2310/344; C12N 2320/51   C-Sets: C12N 2310/321, C12N 2310/3521; (86) International application number: PCT/IB2023/058418 (87) International publication number: WO 2024/042489 (29.02.2024 Gazette 2024/09)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 25.08.2022 US 202263373498 P 02.12.2022 US 202263385887 P 04.08.2023 US 202363517703 P (71) Applicant: Life Edit Therapeutics, Inc. Durham, NC 27701 (US)

(72) Inventors: COYLE, Michael Chapel Hill, North Carolina 27514 (US) CRAWLEY, Alexandra Briner Cary, North Carolina 27511 (US) ELICH, Tedd D. Durham, North Carolina 27705 (US) KELSO, Drew Holly Springs, North Carolina 27540 (US) YU-KEMP, Hui-Chia Chapel Hill, North Carolina 27516 (US) WILEY, David Hillsborough, North Carolina 27278 (US) (74) Representative: Inspicos P/S  Agern Allé 24 2970 Hørsholm 2970 Hørsholm (DK)