(19)

(11)

EP 4 577 659 A2

(12)

(88) Date of publication A3: 18.04.2024 (43) Date of publication: 02.07.2025 Bulletin 2025/27 (21) Application number: 23858303.3 (22) Date of filing: 24.08.2023

(51) International Patent Classification (IPC):  C12N 15/115(2010.01) C12N 15/11(2006.01) C12N 15/63(2006.01) A61K 48/00(2006.01) C12N 15/85(2006.01) (52) Cooperative Patent Classification (CPC): C12N 15/67; C12N 15/86; C12N 2750/14143; C12N 2740/16043; C12N 2840/44 (86) International application number: PCT/US2023/072823 (87) International publication number: WO 2024/044689 (29.02.2024 Gazette 2024/09)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 24.08.2022 US 202263373451 P (71) Applicant: University of Florida Research Foundation, Incorporated Gainesville, FL 32611 (US)	(72) Inventors: WANG, Eric, Tzy-shi Gainesville, FL 32611 (US) ZHOU, Yu Gainesville, FL 32611 (US) (74) Representative: Potter Clarkson  Chapel Quarter Mount Street Nottingham NG1 6HQ Nottingham NG1 6HQ (GB)