(19)

(11)

EP 4 577 858 A2

(12)

(88) Date of publication A3: 10.05.2024 (43) Date of publication: 02.07.2025 Bulletin 2025/27 (21) Application number: 23873538.5 (22) Date of filing: 26.09.2023

(51) International Patent Classification (IPC):  G02B 5/22(2006.01) G02B 5/28(2006.01) G01N 21/64(2006.01) G02B 27/30(2006.01) (52) Cooperative Patent Classification (CPC): G01N 21/6456; A61B 5/0071; G01N 2021/6419; G01N 2021/6421; G01N 2021/6439; C12M 41/36 (86) International application number: PCT/US2023/033734 (87) International publication number: WO 2024/072812 (04.04.2024 Gazette 2024/14)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 27.09.2022 US 202263410557 P 28.09.2022 US 202263410853 P (71) Applicant: The Regents of University of California Oakland, CA 94607-5200 (US)	(72) Inventors: ANWAR, Moshiur M. San Francisco, California 94143 (US) ROSCHELLE, Micah San Francisco, California 94143 (US) (74) Representative: Williams Powell  330 High Holborn London WC1V 7QH London WC1V 7QH (GB)