(19)

(11)

EP 4 578 019 A1

(12)

(43) Date of publication: 02.07.2025 Bulletin 2025/27 (21) Application number: 23858349.6 (22) Date of filing: 25.08.2023

(51) International Patent Classification (IPC):  G16B 20/00(2019.01) G16B 20/20(2019.01) G06N 20/00(2019.01) G16H 10/40(2018.01) C12Q 1/6883(2018.01) G16B 40/00(2019.01) C12Q 1/6869(2018.01) (52) Cooperative Patent Classification (CPC): G16B 20/10; G16B 40/20; G16B 30/00; G16H 50/30; G06N 20/20; G06N 5/01; G06N 7/01 (86) International application number: PCT/US2023/072909 (87) International publication number: WO 2024/044749 (29.02.2024 Gazette 2024/09)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 26.08.2022 US 202263401547 P (71) Applicants: Fred Hutchinson Cancer Center Seattle, WA 98109 (US) University of Washington Seattle, WA 98195 (US)	(72) Inventors: ADIL, Mohamed Seattle, Washington 98195 (US) HA, Gavin Seattle, Washington 98109 (US) REICHEL, Jonathan Brett Seattle, Washington 98195 (US) LOCKWOOD, Christina M. Seattle, Washington 98195 (US) SHREE, Raj Seattle, Washington 98195 (US) (74) Representative: J A Kemp LLP  80 Turnmill Street London EC1M 5QU London EC1M 5QU (GB)